Open AccessCOMPARATIVE IMMUNOPATHOLOGIC STUDIES OF THROMBOTIC THROMBOCYTOPENIC PURPURA, HEMOLYTIC‐UREMIC SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION
Author(s) -
Hayasaka Takashi,
Yoshiki Takashi,
Shirai Toshikazu,
Ninomura Nobumasa,
Itoh Tetsuo
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb02754.x
Subject(s) - fibrin , pathology , thrombotic thrombocytopenic purpura , thrombus , medicine , fibrinogen , platelet , purpura (gastropod) , disseminated intravascular coagulation , coagulation , immunology , biology , ecology
The vascular lesion of thrombotic thrombocytopenic purpura was characterized by two distinct types of changes in the arteriole of the heart and brain: (1) multiple incomplete vascular occlusions due to the subendothelial deposits composed of a homogeneous fibrin fibrinogen‐like substance and platelets without the formation of polymerized fibrin; (2) vascular wall thickening due to the intramural granular deposits of IgM and β1C. A patient with hemolytic‐uremic syndrome 9 days after the onset of the disease, exhibited (1) the formation of fibrin‐thrombi in the glomerular capillary lumens, and (2) the granular deposits of IgM and β1C along the glomerular capillary walls and in the mesangium. In contrast, the case in which the symptoms subsided five weeks after the onset exhibited neither fibrin‐thrombus formation nor the deposits of IgM and βC in the glomeruli. The vascular lesion of disseminated intravascular coagulation accompanied by pancreas carcinoma was located mainly in the capillaries, and were characterized by the formation of numerous fibrin‐thrombi. Although the glomeruli contained numerous thrombi, there was neitherendocapillary proliferation nor deposits of immunoglobulins and complement components.