Open AccessPROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
Author(s) -
Nagashima Kazuo,
Yamaguchi Kazuyoshi,
Yasui Kotaro,
Ogiwara Hiroshi
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb02009.x
Subject(s) - progressive multifocal leukoencephalopathy , pathology , virus , myelin , biology , immunoelectron microscopy , immunofluorescence , virology , staining , jc virus , electron microscope , antibody , central nervous system , medicine , immunology , physics , neuroscience , optics
Mechanism of demyelination in progressive multifocal leukoencephalopathy (PML) was elucidated by demonstrating ultrastructurally the relationship between the affected glial cells and myelin sheaths. The myelinating cells in the central nervous system, namely ollgodendroglias, were specifically attacked by PML‐virus, with eventual primary destruction of myelin sheaths. An attempt to isolate PML‐virus from the autopsy material was made. The presence of virus particles in the extracts from the brain, reactions of virions with antibodies and evidence of virus proliferation in the primary human fetal glial cell culture were shown by various techniques including negative staining, immunofluorescence, immunoelectron microscopy, and electron micrography. The isolated virus was antigenically identical with JC type of papovaviruses.