Open AccessLOCALIZED HEPATIC NECROSIS RELATED TO CYTOMEGALOVIRUS AND TOXOPLASMA GONDII
Author(s) -
Karasawa Tsutomu,
Shikata Toshio,
Takizawa Ichiki,
Morita Koichi,
Komukai Minoru
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb01394.x
Subject(s) - toxoplasma gondii , cytomegalovirus , pathology , necrosis , toxoplasmosis , virology , medicine , biology , immunology , virus , herpesviridae , antibody , viral disease
An unusual hepatic lesion due to both cytomegalovirus and Toxoplasma gondii was described in a patient with angio‐immunoblastic lymphadenopathy treated by predonin. The lesion was a single well‐defined area measuring 1.5 × 1.0 × 0.5 cm of confluent severe hepatic necrosis with multiple cytomegalic inclusion cells and numerous toxoplasmas. The reamining liver had no liver‐cell necrosis, inflammatory cell infiltration, or evidence of either cytomegalovirus infection or toxoplasmosis. These findings suggested us the possibility of symbiosis and synergism of cytomegalovirus and toxoplasma gondii in the liver. Additionally, this was the first demonstration of cytomegalovirus in liver cells by electron microscopy.