Open AccessPRECURSOR T CELL LEUKEMIA
Author(s) -
Morita Takayuki,
Morita Ruriko,
Takagi Shinya,
Shimoyama Norihiko,
Nagai Kazunori
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb00995.x
Subject(s) - leukemia , pathology , medicine , cancer research , biology , computational biology
A case of acute lymphoblastic leukemia with a giant splenomegaly in an 8‐year‐old boy was investigated by immunological, cytochemical and electronmicroscopical techniques. Bone marrow and peripheral blood were largely replaced by large blast cells with a nonconvoluted nucleus. Cytochemically, most of the blast cells showed strong focal acid phosphatase activity. In the surface marker studies, these blast cells formed EAC rosettes but not E rosettes, while they showed positive reactivity with anti‐T lymphocyte serum but not with anti‐B lymphocyte serum. This membrane phenotype E‐, C3R + , T + , B ‐ suggested that leukemic blast cells in this patient presumably originated from precursor T cells.