Open AccessPATHOLOGICAL STUDY ON GOLD IMPREGNATION OF FAT‐STORING CELLS IN HUMAN LIVER
Author(s) -
Kobayashi Yasutsugu,
Fujiyama Susumu
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb00984.x
Subject(s) - pathological , pathology , fatty liver , medicine , disease
Examination of 51 human liver specimens with the modified Kupffer's gold impregnation method confirmed the presence and distribution of fat‐storing cells in various kinds of diseased livers such as fatty liver, acute centro‐lobular necrosis, subacute massive necrosis and cirrhosis as well as in liver cell carcinoma. In normal liver, gold‐reactive fat‐storing cells were distributed in the central area or difisely in lobules. In the liver with marked fatty change and obstructive jaundice, presence of fat‐storing cells was able to be clarified by this method. In cases of acute hepatocellular necrosis, the necrotic areas contained a large number of fat‐storing cells in contrast to adjacent areas. In cases of subacute massive hepatic necrosis and cirrhosis, the areas with abundant newly formed collagen fibers (type III collagen) contained many gold‐reactive fat‐storing cells. In the septa consisting of dense type I collagen flbers, by contraries, fat‐storing cells were hardly visible. The features suggested that fat‐storing cells are closely related to intralobular fibrogenesis. In one case of liver cell carcinoma, there were many gold‐reactive fat‐storing cells in tumor tissue.