Open AccessFAT‐STORING CELLS (ITO'S CELL) OF HUMAN LIVER
Author(s) -
Tanaka Mitsugu,
Fukunaga Masaharu,
Watanabe Kunitake,
Kaneko Yoshihito,
Takahashi Tadashi,
Ishikawa Eisei
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb00983.x
Subject(s) - alkaline phosphatase , parenchyma , glycogen , lactate dehydrogenase , perisinusoidal space , glycogenolysis , circulatory system , pathology , hepatic stellate cell , biology , cell , endothelial stem cell , medicine , endocrinology , chemistry , enzyme , hepatocyte , biochemistry , in vitro
An enzyme histochemical study was carried out on fat‐storing cells, which are distributed in the space of Disse of mammalian liver. The livers used for study consisted of human autopsy materials demonstrating either acute or chronic circulatory disturbance. Fat‐storing cells contain abundant glycogen, and demonstrate a marked γ‐glutamyl transpeptidase activity and a weak lactate dehydrogenase activity. It is highly probable that an active glyconeo‐genesis rather than glycogenolysis is being carried out in these cells. In acute circulatory disturbance, an elevated alkaline phosphatase activity is found in the wall of sinusoids. This phenomenon is a manifestation of activated capillary endothelial cells participating in the regeneration of liver parenchyma. On the other hand, in chronic congestive liver, elevated γ‐glutamyl transpeptidase activity in fat‐storing cells is concerned in the proliferation of fibers in the wall of sinusoids, and elevated pressure in sinusoids is considered to be the main factor in its increased activation.