Open AccessCULTURE OF ISOLATED GLOMERULI FROM NORMAL AND NEPHRITIC RABBITS
Author(s) -
Oite Takashi,
Morita Takashi,
Kihara Itaru,
Yamamoto Tadashi,
Suzukai Yasuhito,
Okada Kananie
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb03281.x
Subject(s) - nephrotoxicity , nephritis , receptor , pathology , glomerulonephritis , medicine , chemistry , endocrinology , kidney
In the autologous phase of nephrotoxic nephritis in the rabbit, many round (Type 111) cells appeared in the glomerular outgrowth. They had receptors for Fc and C3 and a pronounced phagocytic capacity for carbon. The number of Type 111 cells in the glomerular outgrowth from rabbits 8 days after injection of nephrotoxic serum (NTS‐8) was higher than that of NTS‐10 or ‐15. In contrast, they were rarely observed in the outgrowth of glomeruli from normal and NTS‐3 rabbits. The Type I1 (fusiform) cell, a type of intrinsic glomerular cell, was also increased earlier and more markedly in NTS‐8, ‐10, and ‐15 than in normal and NTS‐3 rabbits.