Open AccessA HISTOPATHOLOGICAL STUDY OF THE LIVER IN PARAQUAT POISONING: –An Analysis of Fourteen Autopsy Cases with Emphasis on Bile Duct Injury–
Author(s) -
Matsumoto Toshiharu,
Matsumori Hideaki,
Kuwabara Noriplu,
Fukuda Yoshiro,
Ariwa Rokuro
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb03276.x
Subject(s) - bile duct , cholestasis , intrahepatic bile ducts , pathology , autopsy , paraquat , medicine , biliary tract , liver injury , gastroenterology , biology , biochemistry
Fourteen autopsy cases of paraquat poisoning were studied. Seven of the eight patients who died within 4 days after the ineestion of paraquat showed hepatocytic injury, and three of them revealed bile duct injury. Hepatocytlc injury was similar to that of carbon tetrachloride intoxication. Bile duct injury consisted of epithelial changes of the bile ductules and bile ducts. Cholestasis in the bile ducts was produced by the injury. The affected blle ductules and ducts had hydropic and necrotic epithelium, associated with the infiltration of neutrophils and histiocytes in the lntraductal and periductal tissues. The severity of bile duct injury increased gradually from the bile ductules to the septal bile ducts. The extrahepatic billary tract showed the same injury as the septal bile ducts in one case. It is considered that bile duct injury was produced by a direct corrosive effect of paraquat. Five of the six patients who survived more than 8 days revealed intrahepatic cholestasis, the pathogenesis of which was not clearly understood.