Open AccessEXPERIMENTAL MURINE AMYLOIDOSIS — Evaluation of Induction Methods and Strain Difference —
Author(s) -
Suzuki Toshimitsu,
Ishikawa Shinobu,
Motoyama Teiichi,
Oboshi Shoichi
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb01350.x
Subject(s) - amyloidosis , medicine , adjuvant , freund's adjuvant , pathology , immunology
Several experimental methods inducing murine amyloidosis were tested using six strains of mice including congential asplenic mice and athymic nude mice. Traditional induction method of amyloidosis by casein injections failed to cause amyloidosis in C 3 H/He mice. Single injection with complete Freund's adjuvant reinforced with Mycobacterium butyricum was also unable to induce amyloidosis in C 3 H/He, CBA, and BALB/c mice. Six or four injections with complete Freund's adjuvant at an interval of once a week successfully induced amyloidosis in CBA mice with high incidence but not in C 3 H/He, ICR/SLC, and BALB/c mice. Athymic nude mice with genetic background of BALB/c and congential asplenic mice, cross‐bred with G 57 BL/6 × C 3 H, were free from amyloidosis after six or fourteen injections with the adjuvant. Experimental amyloidosis in mice, therefore, might mainly depend on the strain of mice used and the induction method chosen.