Open AccessPRELYMPHOMATOUS AND LYMPHOMATOUS CHANGES SPLENOMEGALY OF NEW ZEALAND BLACK MICE
Author(s) -
Yumoto Tokichi,
Yoshida Yasuhiro,
Yoshida Haruhiko,
Ando Kazufumi,
Matsui Katsuaki
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb01314.x
Subject(s) - lymphoma , red pulp , pathology , spleen , marginal zone , lymphatic system , histology , follicular lymphoma , white pulp , abnormality , haematopoiesis , follicular phase , medicine , biology , immunology , b cell , antibody , stem cell , psychiatry , genetics
The incidence of splenomegaly was 39.6% in the nontreated group 41.0% in the treated group, not significantly different between both gr Thymic lymphoma group shared 27.6%, while the nonthymic lymphoma gr 67.9%, significantly different between both. Histological findings of sp megaly of the nonlymphoma groups were divided into the following types. 1) follicular form, 2) periarterial lymphatic sheath form, 3) red hematopoietic form, 4) marginal zone form, and 5) red pulp reticulosis Histology of the spleen in the lymphoma group resembled each form of of splenomegaly in the nonlymphoma group. Lymphoma based upon mune abnormality and specific to this kind of mouse in nonthymic lympl continuously takes place from prelymphomatous changes in the nonlympl group. Splenic origin and role of marginal zone of nonthymic lymphor murine lymphoma is discussed.