Open AccessCLINICOPATHOLOGICAL STUDY OF COXSACKIE B VIRAL MYOCARDITIS
Author(s) -
Tanimura Akira,
Nakashima Nobuko,
Komatsu Yoshiharu,
Arakawa Masahiro,
Ookita Yasuo,
Senoo Toshikazu,
Toshima Hironori,
Koike Shigeyuki
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb01313.x
Subject(s) - myocarditis , autopsy , medicine , virus , pathology , enterovirus , titer , infiltration (hvac) , pathological , muscle hypertrophy , immunology , virology , physics , thermodynamics
Autopsy cases of myocarditis caused by Coxsackie viruses in two infants, aged 5 years and 10 months and 12 years, and two adults, aged 24 years and 45 years, were presented. Of the four cases, three revealed a rise in serum neutralization titer to Cox B 4 virus and one to both Cox B 2 and Cox B 4 viruses. Compared with the adult cases, the 2 infant cases showed less inflammatory response with relatively prominent hypertrophy in the heart. Both of the adult cases revealed intensive inflammatory reaction. Extensive inflammatory cell infiltration remained in one of the adult cases though the case survived about 4 years after manifestation of the infection, suggesting possible involvement of immunological factors.