Open AccessNICKEL SULPHIDE‐INDUCED RHABDOMYOSARCOMATA IN RATS
Author(s) -
Yamashiro Shigeto,
Gilman John P.W.,
Hulland Thomas J.,
Abandowitz Henry M.
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb01301.x
Subject(s) - pathology , leiomyosarcoma , fibrosarcoma , rhabdomyosarcoma , mesenchymal stem cell , sarcoma , medicine , biology
Fifty‐nine Fischer rat tumors and eleven Hooded rat tumors induced by intramuscular injection of Ni 3 S 2 were examined and their histopathologic and cytologic characteristics studied. Nine out of eleven Hooded rat tumors metastasized whereas 15 out of 59 Fischer rat tumors metastasized within 30 days. Histopathological characterization of the Ni 3 S 2 ‐induced tumors was made according to their preponderant cellular constitution. They were grouped into six types: well‐differentiated rhabdomyosarcomas, poorly‐differentiated rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal tumors, leiomyosarcoma‐like tumors and fibrosarcoma‐like tumors. Forty‐seven of total of 70 were rhabdomyosarcomas. Tumors with shorter latent periods in Fischer rats and tumors with fleshy and soft texture demonstrated a higher incidence of metastases.