Open AccessULTRASTRUCTURE OF HUMAN HEPATOCELLULAR CARCINOMA
Author(s) -
Isomura Tadashi,
Nakashima Toshiro
Publication year - 1980
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1980.tb00969.x
Subject(s) - hepatocellular carcinoma , pathology , ultrastructure , medicine , biology , cancer research
Twelve human hepatocellular carcinomas (HCC) were studied ultramicros‐copically. In the aspects of development of cytoplasmic organelles, well differentiated cancer cells were similar to the normal hepatocytes. On the other hand, poorly differentiated HCC cells contained little cytoplasmic organel‐le except for relatively developed rER and ribosomes. HCC cells showed not only several differentiations but also many degenerative changes, such as fatty metamorphosis, “dark” and “clear” cells, “fingerprint” formation and myelin‐like figure, and the ultrastructural alterations of the vessels among HCC cells could play one of the most important roles in causing these degenerative changes in human HCC cells.