Open AccessACUTE DIFFUSE INTERSTITIAL FIBROSING PNEUMONITIS AND BILATERAL RENAL CORTICAL NECROSIS
Author(s) -
Mitsuhashi Takehiro,
Hojo Kenji
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb03180.x
Subject(s) - pathology , medicine , fibrinoid necrosis , hyaline , autopsy , fibrin , infiltration (hvac) , necrosis , disseminated intravascular coagulation , lumen (anatomy) , thrombus , vasculitis , cardiology , physics , disease , immunology , thermodynamics
An autopsy case of a 69‐year‐old male with acute diffuse interstitial fibrosing pneumonitis complicated by bilateral renal cortical necrosis was presented. Autopsy revealed acute diffuse interstitial fibrosing pneumonitis, bilateral renal cortical necrosis, non‐bacterial thrombotic endocarditis, involving the aortic and mitral valves, and some interesting vascular lesions, dissemination of fibrinoid change of arterioles and fibrin thrombus of small vessels in various organs; accumulation of polymorphonuclear leukocytes in the lumen of the smaller interlobular arteries and arterioles of the kidney with cellular infiltration and disintegration of the wall; severe disorganization of the wall with intraluminar and intramural fibrinous exudation in smaller branches of the hepatic artery; diminution and disarrangment of muscle fibers and patchy hyalinization in the media of the renal and interlobar arteries. The inter‐relationship between acute diffuse interstitial fibrosing pneumonitis, bilateral renal cortical necrosis which may be regarded as a ‘hallmark’ of the generalized Shwartzman reaction, and disseminated intravascular coagulation was discussed.