Open AccessINTRAHEPATIC BILE DUCT DESTRUCTION IN A PATIENT WITH SARCOIDOSIS AND CHRONIC INTRAHEPATIC CHOLESTASIS
Author(s) -
Nakanuma Yasuni,
Ohta Goroku,
Yamazaki Yoshikiyo,
Doishita Kenji
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb03175.x
Subject(s) - primary biliary cirrhosis , cholestasis , sarcoidosis , bile duct , medicine , intrahepatic bile ducts , pathology , gastroenterology , biliary cirrhosis , autopsy , cirrhosis , primary sclerosing cholangitis , pathogenesis , disease , autoimmune disease
An autopsy case of sarcoidosis with chronic intrahepatic cholestasis for 2 and a half years was presented. Generalized distribution of noncaseating epithelioid granulomas and positive Kveim test were consistent with sarcoidosis. Histological examination of the liver revealed extensive bile duct destruction similar to that seen in the liver of primary biliary cirrhosis. Destructive cholangitis found in the liver appeared to be responsible for long term intrahepatic cholestasis, and no sarcoid granulomas in the liver were found to destroy any bile duct. The possible relation in pathogenesis of the bile duct destruction between primary biliary cirrhosis and sarcoidosis was discussed.