Open AccessGASTRIC CARCINOMA IN DOGS PRODUCED BY THE COMBINED USE OF N‐ETHYL‐N'‐NITRO‐N‐NITROSOGUANIDINE (ENNG) AND GASTRIN
Author(s) -
Kurihara Minoru,
Shirakabe Hikoo,
Yamaya Fumio,
Miyasaka Keiichi,
Maruyama Toshihide,
Izumi Tsuguhiko,
Yasui Akira,
Kamano Toshiki
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb03171.x
Subject(s) - beagle , linitis plastica , antrum , gastrin , carcinoma , medicine , stomach , gastroenterology , pyloric antrum , thickening , pathology , chemistry , secretion , polymer science
Eight beagle dogs of four‐month‐old received both oral administration of N‐Ethyl‐N'‐Nitro‐N‐Nitrosoguanidine (ENNG) and subcutaneous injection of gastrin, and one of them was found to have an annularly infiltrating advanced carcinoma with marked fibrous thickening of the antral wall resulting in stenosis of the antrum (carcinoma scirrhosum) which resembled “Linitis plastica” (Borrmann's type IV carcinoma) in human stomach.