Open AccessEFFECT OF PREGNANCY AND ITS RELATED HORMONES ON THE IN VITRO PROLIFERATIVE ACTIVITY OF MOUSE SPLEEN CELLS
Author(s) -
Hirokawa Katsuilm,
Okayasu Isao,
Hatakeyama Shigeru
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb00949.x
Subject(s) - spleen , endocrinology , medicine , in vitro , hormone , prolactin , lipopolysaccharide , estriol , biology , pregnancy , biochemistry , genetics
The responsiveness of mouse spleen cells to phytohemagglutinin (PHA) and lipopolysaccharide(LPS) was depressed during pregnancy, especially in the early and late phase. In order to explain this, various pregnancy‐related hormones were tested in terms of their effect on in vitro proliferative activity of lymphocytes when stimulated with either PHA or LPS. It was revealed that progesterone and corticosteroid were the moat effective hormones to suppress in vitro proliferative activity of lymphocytes at the physiological level of concentration. The responsiveness of spleen cells to PHA was more susceptible to progesterone than that to LPS, and female spleen cells were more susceptible to progesterone than male ones. HCG did not show apparent suppressive effect on the responsiveness of spleen cells to the mitogens, but to the contrary showed slight enhancing effect on that. Prolactin and estriol did not show any apparent effect on the mitogenic responsiveness of lymphocytes.