Open AccessNONPAPILLARY CARCINOMA IN SITU OF THE URINARY BLADDER
Author(s) -
Iwasaki Hiroshi,
Enjoji Munetomo,
Kano Motonori
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb00930.x
Subject(s) - pathology , urinary bladder , pagetoid , carcinoma in situ , prostatic urethra , medicine , hyperplasia , metastasis , carcinoma , urethra , epithelium , prostate , urology , immunohistochemistry , cancer
Three cases of primary nonpapillary carcinoma of the urinary bladder diagnosed by urinary cytology and multiple biopsies were reported. Bladder specimens of two of the patients were totally embedded for step‐sections that were mapped after histopathologic study. Atypical hyperplasia and carcinoma in situ with foci of microscopic invasion affected thebladder mucosa and extended continuously to the distal ureters as well as prostatic urethra. Multicentric distribution of the abnormal epithelium was deflnite in one case, and the bladder mucosa was extensively denuded in the other case. Metastasis to one of the regional lymph nodes was noted in the remaining one case. The origin of Pagetoid cells occurring in two of the cases is obscure, but we presume that these cells may represent transformed tumor cells showing differentiation toward the surface umbrella cells, or they are derived from Brunn's nests where the cells may gain potential to differentiate to glandular epithelium. ACTA PATH. JAP. 29: 623–633, 1979.