Open AccessTHE DEVELOPMENT OF EXTRANODAL LYMPHOID FOLLICLES IN EXPERIMENTAL BRONCHOPNEUMONIA
Author(s) -
Watanabe Shaw,
Watanabe Keiichi,
Ohishi Takao,
Kageyama Keizo
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb00922.x
Subject(s) - germinal center , bronchopneumonia , lymphatic system , pathology , histiocyte , follicular dendritic cells , biology , infiltration (hvac) , lymphoid hyperplasia , medicine , immunology , immune system , b cell , lymphoma , antibody , antigen presenting cell , t cell , thermodynamics , physics
Extranodal formation of lymphoid follicles was morphologically studied in experimental bronchopneumonia. Control gnotobiotic mice had no peribronchial lymphoid follicles and only lymphatic vessels were traced from the terminal bronchiolar region toward larger bronchi. During the week after intranasal inoculation of mycoplasma pulmonis, lymphoid follicles developed in the terminal portion of the lymphatics by the accumulation of small lymphocytes. A loose network of mesenchymal cells and early infiltration of macrophages, following stromal edema, seemed to play an important role in the early accumulation of lymphocytes. Blastic transformation was seen frequently in the center of the accumulated lymphocytes. Two weeks after inoculation plasma cells emerged conspicuously in the periphery of the lymphoid follicles, and the acute phase of bronchopneumonia began to subside. Typical germinal centers with tingible body macrophages and dendritic reticulum cells developed when the bronchitis perisisted in a chronical manner. ACTA PATH. JAP. 29: 533–543, 1979.