Open AccessTHE DISTRIBUTION AND LOCALIZATION OF IMMUNO‐GLOBULIN IN THE GASTRIC MUCOSA AND GASTRIC CANCER
Author(s) -
Ohta Yasuhiko,
Kino Isamu,
Kato Yo,
Aoyama Yuzo
Publication year - 1979
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1979.tb00921.x
Subject(s) - lamina propria , foveolar cell , stomach , intestinal metaplasia , gastric mucosa , pathology , cancer , antibody , secretory component , epithelium , immunofluorescence , population , biology , medicine , immunology , environmental health
The distribution and localization of immunoglobulin in the gastric mucosa and gastric cancer were studied by means of immunofluorescence. In the lamina propria of the stomach, like the other parts of the gastrointestinal tract, IgA producina cells predominated, but their population density varied from case to case. The main portion of secretion of IgA in the stomach was deep foveolar epithelium. IgA containing epithelial cells in the stomach were much less than those in the intestine, but they increased with advancement of intestinal metaplasia. Some gastric cancer cells retained the ability of secretory component production and took up IgA in their cytoplasm. ACTA PATH. JAP. 29: 523–531, 1979.