Open AccessLIGHT AND ELECTRONMICROSCOPIC OBSERVATIONS ON HEPATIC HEMATOPOIESIS OF HUMAN FETUSES
Author(s) -
Enzan Hideaki,
Takahashi Hiroshi,
Kawakami Masahito,
Yamashita Seiki,
Ohkita T.
Publication year - 1978
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1978.tb01265.x
Subject(s) - haematopoiesis , fetus , mesenchymal stem cell , pathology , biology , stromal cell , stem cell , andrology , microbiology and biotechnology , medicine , pregnancy , genetics
Focusing on hematopoiesis, especially granulocytopoiesis, livers from ten human fetuses between 7 to 13 weeks of gestation were observed with light and electron microscpe. In the hepatic mesenchymal tissue variable number of granulocytes in varying stage of maturation were found from 10 to 13 weeks of gestation. The granules of neutrophils in human fetal livers were classified into three distinct types. The first granules appeared in myeloblasts. The second granules, possibly formed in Golgi complex, were more larger and observed after the promyelocytic stage. The third granules, predominant in mature neutrophils, were pleomorphic. Other than granulo‐cytic, erythrocytic and stromal cells, unclassifiable cells were occasionally encountered. The role of mesenchymal tissues in the granulocytopoiesis, the development of fetal neutrophfls and the problem of hematopoietic stem cells were discussed.