Open AccessSUBACUTE SCLEROSING PANENCEPHALITIS WITH SPECIAL REFERENCE TO THE ULTRASTRUCTURE OF INCLUSIONS IN THE BRAIN AND LUNG
Author(s) -
Ishihara Tokuhiro,
Uchino Fumiya,
Kamei Toshiaki,
Yokota Tadaaki,
Nakamura Hidenori,
Etoh Hirofumi,
Suzuki Eitaroh,
Konishi Shunzoh,
Matsumoto Noboru
Publication year - 1978
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1978.tb01255.x
Subject(s) - pathology , subacute sclerosing panencephalitis , gliosis , ultrastructure , electron microscope , inclusion bodies , lung , cytoplasmic inclusion , peripheral blood mononuclear cell , nerve cells , biology , medicine , cytoplasm , microbiology and biotechnology , measles virus , in vitro , escherichia coli , gene , optics , measles , biochemistry , physics , vaccination
A 7‐year‐old boy, who was diagnosed as typical SSPE by clinical data and laboratory findings, was autopsied and observed by immunofluorescent techniques, light and electron microscope. The morphological characteristics in the brain were perivascular cuffings with plasma cells, lymphocytes and mononuclear cells, gliosis and a large number of intranuclear and intracytoplasmk inclusions in the neuroglias and nerve cells. Various kinds of intranuclear inclusions were elucidated by electron microscopy and the fine structures of these inclusions were described in detail. At least five types of intranuclear inclusions were regarded as specific in SSPE. The presence of intranuclear inclusions of mononuclear cells in the lungs resembling the inclusions in the neuroglias suggested that the disease was not localized in the brain but could be disseminated throughout the body.