Open AccessPATHOLOGICAL STUDY ON AMYLOIDOSIS —RELATIONSHIP OF AMYLOID DEPOSITS IN THE AORTA TO AGING—
Author(s) -
Iwata Takako,
Kamei Toshiakir,
Uchino Fumiya,
Mimaya Hiromichi,
Yanagaki Takayuki,
Etoh Hirofumi
Publication year - 1978
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1978.tb00531.x
Subject(s) - amyloidosis , amyloid (mycology) , autopsy , incidence (geometry) , aorta , medicine , pathological , cardiac amyloidosis , pathology , amyloid fibril , pathogenesis , al amyloidosis , disease , amyloid β , immunoglobulin light chain , immunology , physics , antibody , optics
Senile aortic amyloidosis in 224 autopsy cases over 40 years was investigated comparing cardiac and pancreatic amyloidosis in them. A total of 176 cases of aortic amyloidosis was found for an average incidence of 79%. Under the 5th decade the incidence was 51% and it rose sharply with age and reached 95% in over the 8th decade. The incidence of cardiac amyloidosis also increased with age, but it was always higher in the aorta. Aortic and cardiac amyloid were both positive in the DMAB method for tryptophan. The major part exposed to amyloidosis in the aorta was the media. The medial amyloid consisted of numerous minute deposits and had no relation to atherosclerosis. Some comments about the pathogenesis of senile amyloidosis were also mentioned.