Open AccessMORPHOLOGICAL AND BIOCHEMICAL CHANGES IN THE GASTRIC MUCOSA OF A/HEJ MICE INJECTED WITH A XENOGENEIC STOMACH ANTIGEN
Author(s) -
Watanabe Hiromitsu,
Hirose Fumio,
Takizawa Shoichi,
Terada Yoritaka,
Yumoto Isao Ftokichi
Publication year - 1977
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1977.tb03041.x
Subject(s) - pathology , histiocyte , lymphoma , biology , reticulum cell sarcoma , stomach , pathogenesis , medicine , biochemistry
During the past 6 years we have experienced a total of 6 cases of malignant lymphomas, which originated primarily in the central nervous system. The most reliable diagnostic criteria will be a “perivascular cuffing” by silver impregnation with further spreading of tumor cells to the periphery, a “starry‐sky” appearance consisting of numerous histiocytes with foamy cytoplasm intermingled with tumor cells, and cytological features of the imprint preparation. Since there is a close histologic similarity to extracerebral malignant lymphomas, we would like to propose that these tumors should be regarded as primary malignant lymphomas of the central nervous system instead of mere reticulum cell sarcoma‐microglioma, and also would like to regard the brain to be not an exceptional site other than visceral lymphomas for occurrence of malignant lymphomas. For the pathogenesis of primary intracranial malignant lymphomas, the hypothesis, proposed by Fbigin, of the possible existence of multipotential stem cells in the brain was discussed.