Open AccessACCOMPANYING GASTRO‐ENTERIC LESIONS IN FAMILIAL ADENOMATOSIS COLI
Author(s) -
Watanabe Hidenobu,
Enjoji Muaetomo,
Yao Tsuneyoshi,
Iida Mitsuo,
Ohsato Keiichi
Publication year - 1977
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1977.tb03038.x
Subject(s) - gastro , pathology , medicine , biology , disease , reflux
An effort was made to detect accompanying gastro‐enteric lesions in 26 patients with familial adenomatosis coli (FAG) belonging to 18 pedigrees. One or more types of various gastric lesions were found in 17 (65.4%) of the 26 patients, these gastric lesions consisting of adenoma in 11 cases, fundic gland polyposis in six, carcinoma in three and microcarcinoid in two. The fundic gland polyposis composed of simple hyperplasia of the fundic glands seems to be peculiar to FAC. Duodenal lesions were present in all of the 19 patients examined and consisted of “carcinoma in adenoma” in one case and adenoma in 18 cases in which one had a microcarcinoid in addition. Out of 16 cases investigated through the entire jejunum and ileum by endoscopy and/or at autopsy, eight (50%) showed small polyps limited to the proximal jejunum. Histologic study showed adenoma in five of them. In the remaining three, polyps did seem clearly to be adenoma on endoscopy. Only four (25%) cases revealed one or a few neoplastic lesions restricted to the distal ileum. Histologic study showed malignant lymphoma in one case, and adenoma in three. The present study strongly suggests that accompanying gastroenteric lesions are higher in incidence than previously considered, and special attention should be given to the stomach and small intestine as well as to the colon and rectum. ACTA PATH. JAP. 27: 823‐839, 1977.