Open AccessELECTRON MICROSCOPIC STUDIES ON THE EFFECT OF ACTH AND FLAVIN ADENINE DINUCLEOTIDE ON ADRENOCORTICAL ATROPHY OF HYPOPHYSECTOMIZED RAT
Author(s) -
Koizuka Shinji
Publication year - 1977
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1977.tb00182.x
Subject(s) - atrophy , flavin adenine dinucleotide , flavin group , pathology , endocrinology , medicine , chemistry , biochemistry , enzyme , cofactor
Electron microscopic observation was made on the outer fasciculata cells in the adrenal cortex of hypophysectomized rats receiving 10 nag of FAD and/ or 0.3 mg of ACTH intraperitoneally once a day for 5 consecutive days from 24 hours after hypophysectomy. The simultaneous administration of FAD and ACTH to the hypophysectomized rat was more effective for preventing adrenocortical atrophy induced than the administration of ACTH alone. This effect appeared as clear cells with low electron density. While the characteristics induced by hypophysectomy were the decrease in number of smooth‐surfaced endoplasmic reticulum (SER) and mitochondria and also crista of mitochondria being tubular. The clear cells showed a less degree of their characteristic. From this fact, it is considered that the external FAD acts against fasciculata cells in the adrenal cortex of hypophysectomized rats as a coenzyme for flavin enzyme under ACTH and decreases oxidation‐reaction in mitochondria and oxidative phosphorilation reaction in SER, being induced by hypophysectomy. ACTA PATH. JAP. 27: 637˜645, 1977.