Open AccessHISTOLOGICAL STUDIES ON THE EFFECT OF ACTH AND FLAVIN ADENINE DINUCLEOTIDE ON THE RAT ADRENAL CORTEX ATROPHIED BY HYPOPHYSECTOMY
Author(s) -
Koizuka Shinji
Publication year - 1977
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1977.tb00181.x
Subject(s) - hypophysectomy , adrenal cortex , medicine , atrophy , endocrinology , adrenocorticotropic hormone , cortex (anatomy) , chemistry , biology , hormone , neuroscience
The present study describes the morphological changes in the adrenals of hypophysectomized rats injected 0.03 mg of ACTH and/or 10 mg of FAD intraperitoneally for 5 successive days starting 24 hrs after the operation. The administration of only FAD to intact or hypophysectomized rats showed no morphological change in the adrenal cortex. Simultaneous administration of FAD and ACTH to the hypophysectomized rats is more effective for preventing the atrophy induced than the administration of only ACTH. In these animals, similar morphological observations to those in the control, such as the increased nuclear volume, an increase of clear cells, diminuted numbers of lipid droplets and frequent occurrence of various types of granules, were obtained. FAD seems to be effective, through coexisting with ACTH, for preventing atrophy of the adrenals induced by hypophysectomy. ACTA PATH. JAP. 27: 623˜635, 1977.