Open AccessTRANSPLANTABLE LYMPHOMA PRODUCING TYPE K BENCE‐JONES PROTEIN IN NZB MOUSE
Author(s) -
Yumoto Tokichi,
Okamoto Shiko
Publication year - 1977
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1977.tb00161.x
Subject(s) - bence jones protein , lymphoma , pathology , ascites , transplantation , antibody , neoplasm , medicine , biology , immunology , immunoglobulin light chain
Spontaneous lymphoma occurring in the retroperitoneum in a 13‐month‐old New Zealand Black female mouse, as transplantable to the same strain mice, was subjected to immunological studies by serial transplantation as subcutaneous solid tumor (66A) and bloody ascites tumor (66B). The transplanted tumor‐bearing mice showed M component in the plasma, urine and ascites. It was confirmed as type K Bence‐Jones protein. Speculations were made on the relation between abnormal immunity in NZB mice and lymphoma.