Open AccessAN INHIBITORY EFFECT OF SALIVARY GLAND EXTIRPATION ON THE INDUCTION OF MAMMARY TUMORS IN RATS BY N, N'‐2,7‐FLUORENYLENEBISACETAMIDE
Author(s) -
Hirano Takahiro,
Morris Harold P.,
Jackson Charity M.,
Lewis Jean W.
Publication year - 1976
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1976.tb00884.x
Subject(s) - mammary gland , mammary tumor , salivary gland , atrophy , carcinogen , medicine , endocrinology , adenoma , carcinogenesis , necrosis , pathology , biology , cancer , breast cancer , genetics
N,N' 2 ‐2,7‐Fluorenylenebisacetamide (2,7‐FAA) was administered orally to 34 female, strain AXC/I rats. Nineteen were pretreated with the extirpation of the salivary glands. The remaining 15 rats received no surgical treatment. Six of these 15 unoperated rats developed mammary carcinomas and seven developed tumors at other sites, whereas none of 19 operated rats had mammary tumors but 8 rats had tumors at other sites. No tumor developed in 4 operated control rats that were on normal diet. The results demonstrate that pretreatment with extirpation of the salivary glands inhibited mammary tumor induction in rats by 2,7‐FAA although it did not inhibit induction of other type tumors. The mechanism by which induction of mammary tumors was inhibited is not clear. Ovarian atrophy and hepatic necrosis were observed in both operated and unoperated rats ingesting 2,7‐FAA but did not seem to affect carcinogenesis by the carcinogen. Lower body weight was observed in operated rats but it is not considered to be the major cause of a complete inhibition of mammary tumor induction.