Open AccessCONGENITAL BRAIN AND FACIAL ANOMALIES IN THE D 1 TRISOMY SYNDROME—REPORT OF A CASE AND A REVIEW OF LITERATURE—
Author(s) -
Miyasaki Kichihei,
Murao* Shinichi,
Nakamura** Kazushige,
Hashimoto*** Yoshiho
Publication year - 1976
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1976.tb00879.x
Subject(s) - cerebral hemisphere , pathology , anatomy , medicine , psychology , neuroscience
On 58 cases of D 1 trisomy, which were classified as those with seven separate D chromosomes, including the one in this report, congenital brain and facial anomalies were reviewed and discussed. Congenital brain defects in this syndrome might be classified into three groups: (I) grossly normal brain, (II) absence of olfactory bulbi and tracts, but normally‐separated cerebral hemisphere, and (III) completely or {incompletely uncleaved hemispheres with absence of olfactory bulbi and tracts. 25.9% of the cases were found in group I, 56.9% in group II, and 17.2% in group III, respectively. Although facial anomalies predicted the brain defects in group III, malformations of the face were not concerned with the brain defects in group I and II. There were no cases with both, normal brain and face.