Open AccessINFLUENCE OF BLOOD COLLECTION ON INCIDENCE OF 2,7‐FAA INDUCED RAT LEUKEMIA
Author(s) -
Fujiwara Mutsunori,
Takayama Shojiro
Publication year - 1976
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1976.tb00870.x
Subject(s) - leukemia , pathology , incidence (geometry) , medicine , biology , immunology , optics , physics
The oral administration of N,N'‐2,7‐fluorenylenebisacetamide induced leukemia, especially mature granulocytic leukemia, in rats. The peripheral blood was examined on various schedules, once or twice a week for a long term. The blood volume lost by a blood collection was little, but It was not negligible in small animals such as rats when the loss was repeated. We investigated the relationship between the volume of blood loss and the incidence of leukemia. The incidence of leukemia rose as the volume of blood loss increased. There was a positive correlation between them. The induction of mature granulocytic leukemia was thought to be increased by the promotion of the granulopoiesis which had been supressed by 2,7‐FAA. It was concluded that the blood loss by repeated blood collection for examination raised the Incidence of 2,7‐FAA induced leukemia.