Open AccessPARTICIPATION OF BLOOD BORN CELLS IN RAT MASUGI NEPHRITIS
Author(s) -
Morita Takashi,
Kihara Itaru,
Oite Takashi,
Yamamoto Tadashi
Publication year - 1976
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1976.tb00499.x
Subject(s) - nephritis , pathology , medicine , immunology
Participation of blood born cells in rat Masugi nephritis was investigated with ultrastructural demonstration of peroxidase, in addition to conventional light and electron microscopies. Polymorphonuclear leukocytes appear immediately and transiently after injection of nephrotoxic serum. Hypercellularity in the early stage of the disease is consisted mainly of monocytemacrophage. Proteinuria and infiltration of few monocytes are persistent through the course up to 124 days and focal sclerosis with hyaline material appears in the later stage.