Open AccessSEQUENTIAL MORPHOLOGICAL CHANGES OF ULCERATION IN THE GLANDULAR STOMACH OF RATS INDUCED BY IODOACETAMIDE
Author(s) -
Shirai Tomoyuki,
Takahashi Michihito,
Fukushima Shoji,
Tatematsu Masae,
Hananouchi Motoo,
Ito Nobuyuln
Publication year - 1975
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1975.tb00866.x
Subject(s) - iodoacetamide , gastric mucosa , stomach , intestinal metaplasia , metaplasia , pathology , epithelium , limiting , medicine , anatomy , gastroenterology , biology , biochemistry , mechanical engineering , cysteine , engineering , enzyme
Two groups of 25 male Wistar rats were given 0.1% iodoacetamide (IAM) with or without 0.4% Tween 60 in their drinking water for 12 weeks. Two or three rats from each group were sacrificed at intervals for sequential morphological observations on ulceration of gastric mucosa. The ulcers invariably developed in the fundic region adjacent to the limiting ridge, and they penetrated the muscle coats and extended to the serosal Mng on continuous treatment with IAM for 9 weeks. The ulcers appeared chronic, but when IAM was discontinued the healing process began rapidly and the mucosa regenerated almost completely within six weeks. Regenerating epithelium on areas of ulcer differentiated progressively, and the renewed mucosa showed pyloric metaplasia.