Open AccessFINE STRUCTURAL STUDIES ON THE FATE OF “CASTRATION” CELLS IN THE RAT ADENOHYPOPHYSIS AFTER BILATERAL OOPHORECTOMY
Author(s) -
Nakayama Iwao,
Matsuo Takeshi,
Oyakawa Yukinobu,
Takahara Osamu,
Tsuji Koichi
Publication year - 1975
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1975.tb00864.x
Subject(s) - castration , oophorectomy , medicine , pathology , gynecology , hormone , hysterectomy
The fate of castration cells has been studied by electron microscopy after bilateral, oophorectomy. The castration cells were characterized by a large lake‐like dilatation of rough endoplasmic reticulum which occupied almost the entire cytoplasm, and first appeared at 5 weeks after operation. Castration cells showed cellular suppression after 15 weeks of the experiment but no degenerative changes were observed at any experimental period. At the later stage of the experiment numerous secretory granules reaccumulated in the cytoplasm of the gonadotrophs and concomitantly lake‐like dilatation of rough endoplasmic reticulum in some gonadotrophs gradually decreased and finally disappeared from the cytoplasm. Proportion of the castration cells and mean diameter of the largest cisterane of rough endoplasmic reticulum in each cell attained maximum value at 9 weeks after the operation; thereafter both parameters returned toward normal, although they still remained at a higher level than in controls at 18 weeks after the operation.