Open AccessMYELOPROLIFERATIVE DISORDERS WITH SELECTIVE DIFFERENTIATION TOWARD MEGAKARYOCYTIC CELLS—A CLINICOPATHOLOGICAL STUDY OF THREE AUTOPSY CASES
Author(s) -
Okayasu Isao,
Kajita Akira,
Takemura Tamiko
Publication year - 1975
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1975.tb00859.x
Subject(s) - pancytopenia , autopsy , pathology , myeloproliferative disorders , bone marrow , medicine , leukemia , myeloid , immunology
Three autopsy cases of myeloproliferative disorders with selective differentiation toward megakaryocytic cells were reported with a clinico‐pathological analysis. All of these cases had some common distinctive features; (1) patients, adult of more than 40 years of age, (2) relatively acute fatal course (about 20 to 100 days), (3) continued pancytopenia in the peripheral blood, (4) so‐called blast cells, occasionally showing accumulation, according to the length of total duration, in addition to overwhelming predominance of atypical megakaryocytic cells in the bone marrow, and (5) an increased tendency of fibrillosis in the interstitium of the bone marrow corresponding to the more or less prolonged dura tion of the course, From these facts, they should be compatible with so‐called megakaryocytic myelosis. Some relationship between this dis order and myelogenous leukemia, and infiltrative tendency of megakaryo cytic cells in the extramedullary organs had also been discussed shortly.