Open AccessAN AUTOPSY CASE OF SO‐CALLED DIFFUSE MYELOMA WITH PYROGLOBULINEMIA
Author(s) -
Watanabe Kishichiro,
Konishi Keiko
Publication year - 1974
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1974.tb01244.x
Subject(s) - pathology , autopsy , medicine , multiple myeloma , infiltration (hvac) , spleen , bone marrow , lymph , pathological , thermodynamics , physics
An autopsy case of a 62 year‐old Japanese woman who showed marked hyperglobulinemia and anemia with two kinds of M‐components (IgG(L), Bence‐Jones protein(L)) and pyroglobulin was presented. There was no tumor formation detectable by repeated roentogeno‐graphic examinations in the skeletal system during the clinical course of one year and two months or on the autopsy table. Histologically, however, infiltration of plasma cells showing only mild atypia was noted diffusely in the bone marrow, spleen and lymph nodes. There was also a considerable infiltration of the same in the liver, kidney, ovary and lung. While, throughout the clinical course, leukemic increase of plasma cells in the peripheral blood was not found. No significant underlying chronic disorders were disclosed. Fairly rapid down‐hill course, a myeloma pattern of the serology and the pathological findings of this case denoted primarily a neoplastic proliferative disorder of the plasma cell, and thus this was diagnosed as so‐called diffuse myeloma. A short review was made on the literatures of diffuse myeloma and pyroglobulinemia.