Open AccessA HISTOCHEMICAL STUDY ON THE ACTIVITY OF GAMMA‐GLUTAMYL TRANSPEPTIDASE IN LIVER DISEASE
Author(s) -
Tanaka Mitsugu
Publication year - 1974
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1974.tb01241.x
Subject(s) - gamma glutamyltransferase , pathology , liver disease , medicine , gastroenterology , chemistry , biochemistry , enzyme
Comparative histochemical study for γ‐GTP and alkaline phos‐phatase was performed in several disorders of liver. Areas of extensively proliferated fibrosis in chronic active hepatitis and areas of newly formed fibrosis in cirrhosis showed prominent activity of γ‐GTP but poor activity for alkaline phosphatase. On the other hand, alkaline phosphatase activity was remarkably high in the connective tissue around proliferating bile ductules. Activity of both enzymes was prominent in the bile canaliculi and sinusoidal walls in obstructive jaundice, but marked decrease or loss of activity of the enzymes was observed in the degenerated or necrotic areas. While fatty degeneration of hepatocytes showed no increase in activity of the enzymes, prominent activity of γ‐GTP was noted in the connective tissue surrounding degenerated hepatocytes in alcoholic liver disease. There was marked activity of γ‐GTP in most tumor cells of hepatoma, while in metastatic tumor the activity of both enzymes was noted in only bile canaliculi and sinusoidal wall adjacent to the tumor.