Open AccessA HISTOCHEMICAL and ELECTRON MICROSCOPICAL STUDY OF SO‐CALLED INTRAVENOUS FAT PIGMENT
Author(s) -
Okayasu Isao,
Mori Wataru
Publication year - 1974
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1974.tb00846.x
Subject(s) - fat emulsion , pathology , pigment , autopsy , lipofuscin , electron microscope , chemistry , biology , medicine , parenteral nutrition , physics , organic chemistry , optics
Eighteen autopsy cases which were intravenously administered with fat emulsion (Intrafat) during their clinical course are presented and analysed. The so‐called intravenous fat pigment was seen in the Kupffer cells of the liver, more or less, in ten cases forming brown granules of considerable variety in size, quantity, and quality. Besides, the same kind of granules were found in the cells of the reticulo‐endothelial system, systematically. An analytical study comparing their clinical data and microscopic findings was made. Histochemical and electron microscopical characteristics of the pigment were described, and possible mechanism of its deposition was also proposed. A part of the discussion was extended to the early change due to intravenous infusion of the fat.