Open AccessHISTOLOGICAL and HISTOAUTORADIOGRAPHICAL STUDIES ON THE FETAL ADRENAL CORTEX IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Taira Yoshitsugi
Publication year - 1974
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1974.tb00845.x
Subject(s) - fetus , gestation , adrenal cortex , endocrinology , histology , medicine , cortex (anatomy) , stimulation , pregnancy , biology , pathology , neuroscience , genetics
Cell differentiation in the fetal adrenal cortex of Spontaneously Hypertensive Rats (SHR, Okamoto and Aoki) and normotensive Wistar‐Kyoto Rats was studied histologically and histoautoradiographically at the 19th, 20th, 21st and 22nd day of gestation. The average body weight of the fetuses of SHR was statistically lower than that of the control fetuses but no significant differences were found in the adrenocortical histology. The labeling index of each fetal cortical zone of SHR on the 20th, 21st and 22nd day of gestation was significantly higher than that of normotensive control rats. Only the adrenals on the 19th day of gestation showed a higher labeling index In the control. The results of the present investigation suggest the close relationship between active cell proliferation and DNA synthesis of the adrenal cortex and functional stimulation of the anterior pituitary during the late embryonic life in SHR fetuses.