Open AccessHISTOLOGY AND HISTOGENESIS OF EARLY GASTRIC CARCINOMAS WITH FLAT MUCOSAL ELEVATIONS
Author(s) -
Nagayo Takeo
Publication year - 1974
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1974.tb00821.x
Subject(s) - histogenesis , histology , pathology , medicine , immunohistochemistry
Circumscribed, sessile and flatly elevated early carcinomas were found in 5.5% out of 648 cases of early gastric carcinoma and their histological features were described. Most of the lesions showed highly differentiated tubular adenocarcinomas composed of columnar epithelia and were accompanied by severe intestinal metaplasia in the cancer‐bearing pyloric mucosae. From analysis of the histological structures of the elevated lesions, it was concluded that elevations of the affected mucosae were, regardless of their sizes and shapes, not due to primary growth of the carcinomas but due to reactive growth of the non‐neoplastic gastric mucosae in response to the carcinomas developing In the mucosae between “area gastricae”. Based upon these findings, differences of histological features of the carcinomas from atypical border‐line lesions, which had similar macro‐and microscopical appearances, were also described.