TWO AUTOPSY CASES OF “PULSELESS DISEASE”

Two cases of “Pulseless Disease” are reported. The main lesions In this condition are localized to the arteries of elastic type including pulmonary artery. The chief changes in the initial stage are limited to the adventitia and outer portion of media, based on an inflammatory reaction, which in turn brings about several following changes in arterial wall; marked fibrous thickening of adventitia, destruction of media and intimal thickening. In “Pulseless Disease,” the lumen of the affected artery tends to become stenosed or obstructed, but can also be dilated and partially aneurysm‐like. The stenosis of the lumen is chiefly caused by the contraction of the adventitial fibrosis overcoming the pressure on the arterial wall, promoted with the intimal thickening. Dilatation of that may be caused by increased arterial pressure, which exceedes the contracting effect of the wall, and is also influenced by the duration of the disease.