Open AccessTHOROTRAST TUMORS IN JAPAN ‐ REPORT OF TWO CASES WITH AUTOPSY FINDINGS AND A BRIEF REVIEW OF LITERATURE ‐
Author(s) -
Fujikura Takashi,
Kawai Sadao
Publication year - 1973
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1973.tb00781.x
Subject(s) - thorotrast , lymph , pathology , thorium dioxide , lymph node , medicine , autopsy , chemistry , nuclear chemistry
Two cases of thorotrast tumor were reported; in one of them, it primarily developed in the liver, and in the other it originated in the neck. Both cases revealed an intimate correlation between tumor development and thorotrast deposition, which seemed to be fixed along the lymphsystem in the Glisson's capsule and hilar lymph nodes, although histological findings in some parts especially central and midzonal part of liver lobules indicated considerable mobility of thorotrast deposits. This is probably because lymph nodes, which receive lymph flowing out of the respective organs remove the thorotrast granule from the lymph and are deteriorated by them. Deterioration of the lymph nodes dams the stream of thorotrast granules and fix their deposits. Fibrosis around the thorotrast granules is due to reaction of connective tissue around them as a foreign body and radioactive substance. Malignant tumors of the two cases originated nearby areas with marked thorotrast deposition.