Open AccessPRIMARY MIXED CARCINOMAS OF THE BRONCHUS
Author(s) -
Chaudhuri M. Ray
Publication year - 1972
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1972.tb01852.x
Subject(s) - histogenesis , adenocarcinoma , pathology , bronchus , pathological , basal cell , carcinoma , large cell , medicine , cell , lung cancer , lung , cancer , biology , respiratory disease , immunohistochemistry , genetics
Primary mixed carcinomas of the bronchus are found to occur more frequently than previously reported. Forty‐two cases of primary mixed carcinomas of the bronchus were seen at the London Chest Hospital from 1966 to 1969. During this time, 3853 patients were admitted to the hospital and among them 733 had bronchial carcinomas. In 27 instances, the tumour histologically was squamous and adenocarcinomatous in type. Of the other 15; squamous and oat cell characters, and undifferentiated carcinoma of large polygonal cell and adenocarcinomatous characters were present in five instances; adenocarcinoma and oat cell, and undifferentiated carcinoma of large polygonal cell and oat cell characters were present in two instances; and only one had mixed alveolar and oat cell carcinomatous pattern. A study of the pathological changes in these mixed bronchial carcinomas revealed little differences, if any, from a primary bronchial carcinoma. The histogenesis of these mixed carcinomas remains uncertain. The most plausible view is that they arise by divergent differentiation from the descendants of the original multipotent cancer cells. ACTA PATH. JAP. 22:555–564, 1972.