Open AccessA PATHOLOGICAL STUDY ON THE JUVENILE TYPE OF CHRONIC MYELOID LEUKEMIA
Author(s) -
Takanashi Riichiro
Publication year - 1972
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1972.tb01847.x
Subject(s) - pathological , juvenile , pathology , myeloid leukemia , medicine , biology , immunology , genetics
The pathological findings In four infants with chronic myeloid leukemia (GML) of the juvenile type were compared with those in adults with GML. In three cases Hb‐F of erythrocytes was positive and Ph 1 chromosome was negative. In one case these examinations were not performed. The bone marrow shows a wide range of maturation of granulocytes in both types. Immature forms, however, are more abundant in the juvenile type than in the adult type. Advanced structural alteration as splenoid marrow is rare in the juvenile type. Decrease of megakaryocytes is more profound than that of erythroblasts. Involvement of lymph node and lymphatic apparatus is much more extensive in the juvenile type than in the adult type. Proliferation of erythroblasts is prominent in foci of extramedullary infiltration, frequently showing a nodular pattern. For examination of Hb‐F of erythrocytes in formol‐flxed paraffin sections, alkali denaturatlon followed by spectrophotometry with UMSP‐I was applied. The denaturatlon rate of erythrocytes In the liver is lower In the juvenile type of GML than in the control adults and adult type of CML. ACTA PATH. JAP. 22:489–508, 1972.