Open AccessAN AUTOPSY CASE OF CRONKHITE‐CANADA'S SYNDROME ‐GENERALIZED GASTROINTESTINAL POLYPOSIS, PIGMENTATION, ALOPECIA and ONYCHOTROPHIA –
Author(s) -
Shibuya Chiken
Publication year - 1972
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1972.tb01839.x
Subject(s) - gastrointestinal tract , pathology , medicine , etiology , mucus , rectum , atrophy , biology , gastroenterology , ecology
A case of Cronkhite‐Canada's syndrome characterized by diffuse gastrointestinal polyposis, alopecia, nail atrophy, and pigmentation of the skin is reported. These ectodermal changes are probably a part of a generalized nutritional deficiency state and their clinical prominence may be related to the extensive involvement of all segments of the digestive tract. The macroscopic findings of the gastrointestinal tract were different at various sites, but the microscopic picture was uniform and characterized by proliferation of mucus secreting glands and cyst‐like dilations of the gland excepting the cancerous lesions of the sigmoid and rectum. The etiology of the syndrome remains obscure.