Open AccessTHE METABOLIC EFFECT OF PYRIDINOLCARBAMATE IN RATS
Author(s) -
Mrhova Olga,
Shimamoto Takio,
Numano Fujio
Publication year - 1972
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1972.tb00746.x
Subject(s) - pathology , medicine , physiology , computational biology , biology
The effect of peroral application of pyrldinolcarbamate (30 mg/kg/day) was studied in rats which were kept either on a standard laboratory diet, or on a diet containing a large amount of fat (40%) and cholesterol (5%). PDC significantly increased the lactate dehydrogenase activity in the aortae of rats kept on a standard diet, and the malate dehydrogenase activity in the aortae of rats kept on high‐fat diet. In experiments in vitro , PDC increased the activity of the aortic lactate and malate dehydrogenase. This effect was most pronounced at higher concentrations of PDC in the incubation medium (3000μg/ml). In the rat myocardium, activity of the enzymes studies was not noticeable influenced by PDC administration. Under the given experimental conditions, pyrldinolcarbamate increased the activity of enzymes participating in the citrate cycle and glycolysis. In view of the present knowledge of the role of the vascular wall metabolism in atherogenesls, this effect could contribute to greater resistance of the vessel wall against the development of atherosclerotic changes.