Open AccessDEGRANULATION AND REGRANULATION OF PANCREATIC ISLET CELLS OF ALLOXAN DIABETIC RATS: II. ELECTRON MICROSCOPIC STUDY
Author(s) -
Tomita Tatsuo
Publication year - 1972
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1972.tb00742.x
Subject(s) - alloxan , degranulation , islet , pathology , diabetes mellitus , medicine , chemistry , endocrinology , receptor
The ultrastructural study of pancreatic islets from the alloxanized rats was performed along with histochemical studies. During the initial stages of hyperglycemia, B cell degranulation was progressive, while A cells were left intact. The presence of remaining B granules was confirmed in the disintegrated cell debris and also in the macrophages up to 24 hours. The islets from the third day after alloxan showed only a few degranulating B cells and the majority were small poorly differentiated agranular cells and A cells. Major components of small islets from 7 days through 28 days were A and D cells, while some large islets were composed of a mixture of well regranulated A cells and sick B cells. The significance of agranular cells as the possible origin of the differentiated A and B cells was suggeste.