Open AccessSURFACE MEMBRANE OF LYMPHOCYTES
Author(s) -
Watanabe Shaw,
Mikata Atsuo,
Tadakuma Takushi,
Niki Rikio,
Kageyama Keizo
Publication year - 1971
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1971.tb00138.x
Subject(s) - antigen , ouchterlony double immunodiffusion , antibody , immunology , heterologous , ferritin , lymphocyte , pathology , cytoplasm , chemistry , biology , medicine , microbiology and biotechnology , antiserum , biochemistry , gene
Injection of serum or immunoglobulin, obtained after immunization of lymphocytes or thymocytes, caused lymphopenia either in normal rats or in RES‐blocked rats. Control rabbit serum, immunized with rat liver, caused leucocytosis instead of lymphopenia. The dose of administration was related to the degree of leucopenia. The presence of lymphocytic specific antigen determinants was confirmed with Ouchterlony agar plate method as well as other various heterologous antigens. Antilymphocytic antibody disappeared after absorption with lymphoid cells. Ferritin‐conjugated‐ALG were adsorbed along the plasma membrane of lymphocyte and did not infiltrate into the cytoplasm.