Open AccessMICROCIRCULATORY DISTURBANCE PRODUCED BY SOLUBLE IMMUNE COMPLEXES
Author(s) -
Nakajima Sohta
Publication year - 1971
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1971.tb00133.x
Subject(s) - guinea pig , mesentery , pathology , microcirculation , chemistry , disturbance (geology) , in vivo , immunology , biology , medicine , paleontology , microbiology and biotechnology
Microcirculatory disturbance produced on normal guinea pig mesentery by soluble IgG complexes was observed by in vivo microscopy for one hour. Soluble IgG complexes dropped onto normal guinea pig mesentery produced acute local vascular reactions which were characterized by plasma exudation, stasis, sticking and emigration of leukocytes and hemorrhage. These changes were recognized only in the venules. Evidences have been presented to show that these changes were chiefly brought about by the plasma exudation from the venules. Analyzing various phases of immunologic vascular reactions, the importance of the flow dynamic changes of microcirculatory region was emphasized.