Open AccessEXPERIMENTAL ANALYSIS ON PATHOGENESIS OF THE SECONDARY NODULE LESIONS IN LYMPH NODES INDUCED BY SHOCK
Author(s) -
Kojima Mizu,
Takahashi Kiyoshi,
Yamaguchi Akihiko,
Sue Akira,
Terashima Kazuo
Publication year - 1971
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1971.tb00132.x
Subject(s) - pathology , lymphatic system , pathogenesis , shock (circulatory) , nodule (geology) , hypoxia (environmental) , lymph , atrophy , ligation , medicine , lymph node , biology , anatomy , chemistry , oxygen , radiology , paleontology , organic chemistry
Various animal experiments were undertaken with the object of clarifying the pathogenesis of cellular destruction and resultant atrophy of secondary nodules in lymphatic tissues appearing in shock. Reproduction of such changes were successfully performed in the experiments of hemorrhagic shock and endotoxin shock. From the results of experiments on various types of hypoxia, it was deduced that the karyorrhetic phenomenon and sequential atrophy of secondary nodules are closely related to such a hypoxia. Vascular ligation of the lymph node and experiment under high oxygen pressure led to a conclusion that lymphatic tissue anoxia usually occurring during shock plays a more important role in production of such a phenomenon in the secondary nodules than the direct effect of oxygen supply from the secondary nodule arterioles.